Food poisoning can jeopardize human health. Manufacturing and personal hygiene has very important role in its prevention. The causes of food poisoning are different, and the best known are bacteria. In addition to bacteria, plant toxins, chemical compounds and additives in food can also cause severe food poisoning. Bacteria poisoning is frequent because of poor hygienic practice and inappropriate ways of food preservation. Confusion of the distinction of edible from poisonous plants is a common cause of poisoning whit plant toxin, while poisoning with chemical substances usually occurs because of their presence in food through the soil, air and water or its willful injection in food. Poisoning whit food additives usually occurs due to over-consumption of food containing them. In order to prevent food poisoning certain human body systems are participating in the removal of toxic substances. However, the body is not one hundred percent effective in terms of prevention, so it is necessary to know other ways of prevention of food poisoning.