Today, tourism is one of the fastest growing and most profitable industries. Globalization, technological development of transport, as well as extensive infrastructure have greatly influenced tourism development. The number of trips is growing from year to year, and it is becoming normal to travel to distant destinations. Although tourism has a number of advantages and disadvantages, there is also a vulnerability to the impact of pandemics. The aim of this paper is to determine the impact of pandemics on tourism and the hotel industry. The subject of this paper is to show how bird and swine flu, and the latest COVID-19 crisis have affected tourism and the hotel industry. The effects of bird and swine flu and COVID-19, ie coronavirus, were observed in this paper. Bird and swine flu together did not make as many losses and negative impacts on tourism and the hotel industry as COVID-19 had. What they all have in common is that in countries where they had a significant occurrence, they had a negative impact on economic trends, while COVID-19 was quarantined for the first time by almost the entire world. In Croatia, there was no significant impact of bird and swine flu on the economy, but COVID-19 left scars, many of which will recover in tourism and the hotel industry for years.